Polymer-Supported α-Acylamino Ketones: Preparation and Application in Syntheses of 1,2,4-Trisubstituted-1H-imidazoles
نویسندگان
چکیده
منابع مشابه
Synthesis and biological screening of di- and trisubstituted imidazoles.
Disubstituted imidazoles were prepared by reacting appropriate phenylglyoxal with different aryl aldehydes in the presence of ammonium acetate. Trisubstituted imidazoles were prepared by reacting disubstituted imidazoles with chlorobenzene in the presence of catalytic amount of triethylamine (TEA). The synthesized compounds were characterized on the basis of IR, 1H-NMR and mass spectral data an...
متن کاملSynthesis of trifluoromethyl ketones using polymer-supported reagents.
A two step synthesis of trifluoromethyl ketones from aldehydes is reported. A combination of polymer-supported reagents and sequestering agents were employed to effect the transformation without the need for chromatographic purification.
متن کاملPreparation, Characterization, and Application of Nanospherical α-Fe2O3 Supported on Silica for Photocatalytic Degradation of Methylene Blue
In the research, spherical α-Fe2O3 NanoParticles (NPs) were synthesized through Forced Hydrolysis and Reflux Condensation (FHRC) process and were supported on the surface of silica sand by Solid-State Dispersion (SSD) method. Characterization of silica and α-Fe2O3/SiO2 catalyst was done using Fourier-Transform InfraRed (FT-IR) spectrosc...
متن کاملDesign, preparation and characterization of a novel BiFeO3/CuWO4 heterojunction catalyst for one-pot synthesis of trisubstituted imidazoles
In this work a novel heterojunction catalyst have been synthesized and employed as a highly efficient catalyst for one-pot synthesis of substituted imidazoles. Analytical methods including Fourier transform infrared (FT-IR), diffuse reflectance spectroscopy (DRS), X-ray diffraction (XRD), Energy- dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM) and Vibrating Sample Magnom...
متن کاملTrisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors†
Mycobacterium tuberculosis glutamine synthetase (MtGS) is a promising target for antituberculosis drug discovery. In a recent high-throughput screening study we identified several classes of MtGS inhibitors targeting the ATP-binding site. We now explore one of these classes, the 2-tert-butyl-4,5-diarylimidazoles, and present the design, synthesis, and X-ray crystallographic studies leading to t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Combinatorial Chemistry
سال: 2009
ISSN: 1520-4766,1520-4774
DOI: 10.1021/cc800210q